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Bisphenol A is used in the manufacture of epoxy resin, polycarbonate, and corrosion-resistant unsaturated polyester-styrene resins required for food packaging materials in industrial processing. Some reports indicated the possibility of harmful effects on rats. In this study was carried out to examine the effects of second generations which was exposed maternally. And the detennination of Bisphenol A in blood according to the OSHA High Performance Liquid Chromatography(HPLC) guideline. The method involved blood extraction using methylene chloride. And it was evaluated developmental and teratogenic effects in pregnant rats and second generations. The results obtained were as follows; There was a significant increase in the body weights and treated groups Fl female in liver, spleen, kidney but according to dose-response. FI female rat’s relative body weight and absolute body weight are not different. There was a significant increase liver, spleen, kidney organ weight and reproductive organ weight epididymis, prostate gland in FI male rats. Estrus was cycled earlyer than that of control group. Identification and quantitation of Bisphenol A in the blood was detected in 2O,OOO㎍/kg group about 1㎍/ml, 2OO㎍/kg group about O.9㎍/ml. From those results, it could be concluded that the effect of pregnant rat and second gene ration(Fl) by Bisphenol A treatment during lactational period were estrogenic and Blsphenol A was remained in serum at low level.
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